The European Medicines Agency has recommended Korjuny for the treatment of patients with intraperitoneal malignant ascites.
In its October 2024 meeting, the European Medicines Agency Committee for Medicinal Products for Human Use gave the green light forThe active substance of Korjuny is catumaxomab, a monoclonal bispecific trifunctional antibody that targets epithelial cell adhesion molecules on tumor cells and CD3 antigen on T cells. It induces an immunoreaction against EpCAM-expressing tumor cells.
EpCAMs are transmembrane glycoproteins that mediate cell adhesion in epithelia and are involved in cell migration, proliferation, and differentiation. Catumaxomab was registered in 2009 for the treatment of malignant ascites of various EpCAM-positive malignancies, including ovarian, gastric, breast, andPuncture-free survival was significantly longer in the catumaxomab group as was median time to next paracentesis . In addition, catumaxomab patients had fewer signs and symptoms of ascites than control patients, with overall survival showing a positive trend for the catumaxomab group.
Korjuny must be administered under the supervision of a physician experienced in the use of anticancer medicinal products. The most common side effects of the treatment are pyrexia, abdominal pain, nausea, and vomiting.
Noncolorectal Gi Cancer Malignant Ascites Drug/Treatment Safety Drug Safety Treatment Safety Drug Development Drug Discovery Drug Pipeline Drug Development Pipeline Drug Legislation Drug Registries Drug Registry Drug Regulation Infectious Disease Diagnostics Ascites Peritoneal Cavity Fluid Peritoneal Fluid Excess Hydroperitoneum Cancer
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