Aripiprazole enhances the entrainment to external light-dark cycles by weakening the synchronization between neurons in the central circadian clock, thereby improving the symptoms of circadian rhythm sleep disorders.
While aripiprazole has long been a standard treatment for psychiatric disorders, such as schizophrenia and bipolar disorder, recent studies indicate that it is effective in treating circadian rhythm sleep disorders, including delayed sleep-phase syndrome. This condition causes patients to sleep and wake extremely late at times. However, the precise mechanism through which aripiprazole addresses these sleep disorder symptoms remains elusive.
Researchers from the University of Tsukuba have discovered that aripiprazole can directly affect the mammalian central circadian clock; specifically, it can modulate the photic entrainment in mice. Located in the hypothalamic suprachiasmatic nucleus , the central circadian clock comprises clock neurons that synchronize with each other, maintaining a rhythm of approximately 24 h.
These findings suggest that the efficacy of aripiprazole in alleviating circadian rhythm sleep disorder symptoms in psychiatric patients might be attributed to the modulation of the circadian clock by the drug. This study expands the potential clinical usage of aripiprazole as a treatment for circadian rhythm sleep disorders.
This work was supported by Japan Agency for Medical Research and Development , Japan Society for the Promotion of Science KAKENHI , Japan Science and Technology Agency CREST , JSPS KAKENHI Grant-in- Aid for Scientific Research [:19 K08037 and 22K07571 to TK], The Naito Foundation , TMFC Japan Foundation for applied Enzymology , and JSPS Grant-in-Aid for JSPS Fellows .
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