A new method called CASTER allows researchers to analyze entire genomes simultaneously, unlocking new possibilities for understanding evolutionary relationships.
Electrical engineers at the University of California San Diego have developed a groundbreaking approach to comparative genomics, named CASTER (Comparative Analysis of Entire genomes Through Scalable Representations). This innovative method allows researchers to analyze entire genomes simultaneously, opening up new avenues for understanding evolutionary relationships across vast geological time scales.
Prior to CASTER, comparative genomic analyses were limited to studying smaller, selected regions of genomes, hindering a comprehensive understanding of evolutionary processes. The sheer volume of sequenced genomes, both from living and extinct species, has made analyzing full genomes essential. CASTER addresses this challenge by providing a scalable and interpretable framework for biologists to delve into the intricacies of genome evolution.The new method, detailed in a paper published in Science, offers several advantages. Firstly, it enables the analysis of all genomic positions, providing a more complete picture of evolutionary history. Secondly, CASTER utilizes complex models to account for the intricate patterns of genomic change, leading to more accurate phylogenetic reconstructions. Finally, the method produces interpretable outputs that reveal not only species relationships but also the mosaic nature of evolutionary histories across different genomic regions. This detailed insight allows researchers to pinpoint specific genes or regions that have been shaped by selective pressures and understand their functional implications. Researchers believe CASTER will revolutionize the field of phylogenomics, providing unprecedented insights into the organization of the tree of life and the forces that have shaped the diversity of life on Earth
GENOMICS EVOLUTION PHYLOGENOMICS COMPARATIVE ANALYSIS CASTER
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