An experimental Alzheimer's drug slowed cognitive decline in a trial but may carry a risk of dangerous side effects for certain patients
slowed cognitive decline in a closely-watched trial but may carry a risk of dangerous side effects for certain patients, according to new data presented on Tuesday.
The trial showed no benefit on the CDR-SB measure for some patients with a genetic risk of developing the mind-wasting disease. The APOE4 carriers did show improvement on the trial's secondary goals, including other measures of cognition and daily function. Overall, lecanemab patients benefited by 23% to 26% compared with a placebo on these secondary trial goals.
Earlier this year, Stat reported that an 87-year-old man in the study, who was on the blood thinner Eliquis, also developed a brain hemorrhage and died.Cheung said Eisai has protocols in place for monitoring brain swelling and sees no need for restrictions on which patients might be eligible for lecanemab treatment.
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