A study in BMCMedicine finds beneficial effects of ketogenic diet in overweight and epileptic patients. However, it is accompanied by a clinically significant increase in LDL cholesterol. Further studies are warranted.
]. Though our aggregate results also confirm an increase in LDL-C and total cholesterol with KD and K-LCHF, respectively, it is important to note that an increase in either of these levels does not necessarily signify a potentially deleterious cardiovascular end-point. This qualification derives from the fact that LDL particles are widely heterogeneous in composition and size, with small dense LDL particles being significantly more atherogenic than larger LDL particles [].
Our findings are useful to support the generation of evidence-based recommendations for clinicians contemplating use of KD in their patients, as well as for the general population. We further emphasize the importance of consultation with healthcare professionals before utilizing KD and any other dietary interventions. We demonstrated the benefits of KD on various outcomes in the short term.
]. Thus, we cannot be certain how the precise degree of ketosis contributed to the beneficial effects noted.Beneficial associations of practicing KD were supported by moderate- to high-quality evidence, including weight loss, lower triglyceride levels, decreased HbA, RER, and decreased seizure frequency. However, KD was associated with a clinically meaningful increase in LDL-C.
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