Trial finds chatbots have mixed effectiveness in increasing COVID-19 vaccineconfidence in Asia lshtmpress NaturePortfolio
. Our formative data on chatbot users’ adaptions to the intervention suggested considerable interest in the public toward vaccine-related chatbots, as corroborated by the proportion of chatbot users who agreed or strongly agreed with the question: “I intend to use the chatbot again” [Thailand = 87%; Hong Kong = 73%; Singapore = 82%].
This study is a multisite, parallel RCT on multilingual vaccine chatbots. It was conducted in three Asian regions, one being upper-middle-income and two being high-income. As this study was conducted during the aggressive implementation of containment interventions such as social distancing rules and mandatory vaccine pass schemes by the governments in our study sites, we employed the RCT design to evaluate the impact of the chatbot intervention.
Nevertheless, our study has several limitations. First, our sample sizes across all three regions were smaller than our target sample sizes. A combination of heightened risk perception owing to increased daily case counts and public health measures, such as school-based vaccine rollout and vaccine mandates, led to surges in vaccination uptake in our study locations, leaving only a small population who remained unvaccinated during our study period.
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