'There are specific brain mechanisms that get activated when we expose ourselves to specific type of foods,' study leader Sabrina Diano said.
, the authors showed the high fat diet seemed to trigger changes in cell powerhouses—or mitochondria—of microglial cells, causing them to spring into action.
The effect of the microglia springing into action was that neurons received an inflammatory signal, leading the animals to eat more food. The animals became obese. They were able to show that the way UCP2 changes the mitochondria, and in turn how the microglial cells help to trigger inflammatory signals, could play a"pivotal role" in hypothalamic inflammation and metabolic problems.
"There are specific brain mechanisms that get activated when we expose ourselves to specific type of foods. This is a mechanism that may be important from an evolutionary point of view. However, when food rich in fat and carbs is constantly available it is detrimental."
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