A drug targeting mRNA essential for APO C-III production provided a 50% reduction in triglycerides in BRIDGE-TIMI 73a, the largest ever observed in a controlled trial.
ATLANTA — A novel antisense therapy called olezarsen reduced triglycerides by approximately 50% with either of the two study doses relative to placebo and did so with a low relative risk for adverse events, new data from a phase 2b trial showed.
The drug also produced meaningful improvements in multiple other lipid subfractions associated with increased cardiovascular risk, including ApoC-III, very low–density lipoprotein cholesterol, ApoB, and non-LDL cholesterol. High-density lipoprotein cholesterol levels were significantly raised.The effect was seen across all the key subgroups evaluated, including women and patients with diabetes, obesity, and severe as well as moderate elevations in TGs at baseline, Bergmark reported.RNA.
Patients were eligible for the trial if they had moderate hypertriglyceridemia, defined as a level of 150-499 mg/dL, and elevated CV risk or if they had severe hypertriglyceridemia with or without other evidence of elevated CV risk. The primary endpoint was a change in TGs at 6 months. Complete follow-up was available in about 97% of patients regardless of treatment assignment.
Lipid Management CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Triglycerides Hypertriglyceridemia Hypertriglyceridaemia Aminotransferase Ast Liver Enzymes Liver Studies Alt Transaminase Ldl Cholesterol Low-Density Lipoprotein Cholesterol High-Density Lipoprotein Cholesterol Hdl-C Hdl Hdl Cholesterol Lipoproteins
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