Unlike antibodies elicited by mRNA vaccines against COVID19, some non-neutralizing, afucosylated IgG antibodies specific to SARSCoV2 may be associated with progression to more severe disease, according to new research in ScienceTM.
). Fourth and finally, the in vivo model described here is not a model of severe COVID-19 pathogenesis. The development of animal models that more faithfully recapitulate the risk factors and immune responses associated with severe disease in humans are necessary in this endeavor.
For the animal studies, no statistical methods were employed to predetermine sample size. Mice were randomized to achieve equal distribution of age and sex . Treatment groups were consistently blinded to the person involved in treatment administration and tissue processing. Cellular, cytokine, and chemokine measurements were performed in duplicate and data are representative of 2-3 independent experiments.