A pilot study suggests the ketogenic diet may ease symptoms of schizophrenia and bipolar disorder and reduce weight gain associated with metabolic syndrome.
Participants who adhered to the high-fat, low-carb diet experienced a 30% reduction in psychiatric symptoms and an average 10% reduction in weight. Recent research supports the hypothesis that psychiatric illness may stem, at least in part, from deficits in brain metabolism and that a keto diet may be neuroprotective by reducing inflammation and oxidative stress.
Investigators monitored blood ketone levels at least once a week and defined participants as keto-adherent if their levels were 0.5-5 mM for 80%-100% of the times they were measured. The research team tracked participants' adherence to the diet by weekly measurement of blood ketone levels. On average, participants experienced a 10% reduction in weight and BMI. Waist circumference was reduced by 11%, fat mass index dropped by 17%, and systolic blood pressure decreased by 6%. In addition, metabolic markers including visceral fat, inflammation,The study's limitations include its small sample size, the lack of control arm, and short duration.
Metabolic Syndrome Metabolism Metabolic Ketogenic Diet Diet Bipolar Disorder Bipolar Mania Manic Depression Bipolar Affective Disorder Lipids Lipid Management Blood Mental Illness Mental Disorder Psychiatric Disorder Psychiatric Illness Obesity Obese Body Mass Index BMI Insulin Resistance CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors
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