Initiating biologic therapy early in order to achieve transmural healing led to better long-term outcomes in patients with Crohn's disease.
Early initiation of biologic therapy in patients with Crohn ’s disease is associated with higher rates of transmural healing and leads to improved long-term outcomes.In CD, early initiation of biologic therapy has shown higher rates of clinical remission and lower rates of relapse than late initiation .
A retrospective study assessed the impact of the timing of biologic therapy initiation on transmural healing rates and long-term outcomes in adult patients diagnosed with CD from 1975 to 2022. The primary outcome was the achievement of transmural healing, assessed using magnetic resonance enterography at 12 ± 6 months post-therapy initiation and defined as the complete normalization of all MRE parameters .Researchers included 154 patients with CD, among whom 59 and 95 had early and late initiation of biologic therapy, respectively.
Patients with early initiation of biologic therapy were 3.23 times more likely to achieve transmural healing than those with late initiation (Those with early initiation of biologic therapy also showed better MRE response rates than those with late initiation (36% vs 22%;"Our findings underscore the significance of initiating biological treatment within the first year of diagnosis for achieving higher rates," the authors wrote.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Crohn Disease Regional Enteritis Crohn Crohn’S Biologic Therapy Biologics Intestinal Surgery Gastrointestinal Surgery GI Surgery Grant Surgery Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks Board Certification Boards Board Recertification Hospitals Portugal Portuguese Republic Remission
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