New trial confirmed safety and efficacy of a subcutaneous add-on therapy for uncontrolled COPD.
Dupilumab significantly reduced exacerbations and improved lung function in adults with uncontrolled chronic obstructive pulmonary disease and type 2 inflammation, based on data from more than 900 individuals.
The study population included adults aged 40-85 years with physician-diagnosed COPD for at least 12 months who had received background triple inhaler therapy for at least 3 months and at a stable dose for at least 1 month. All participants were current or former smokers with a smoking history of at least 10 pack-years.
Improvement in respiratory symptom severity based on the St. George's Respiratory Questionnaire was another secondary endpoint, and changes in total score were greater in the dupilumab group than in the placebo group . With the NOTUS study,"two randomized trials have now shown near identical reductions in exacerbation frequency in a difficult-to-treat population of patients with COPD with type 2 inflammation and frequent exacerbations," as well as a significant and meaningful improvement in lung function, Bhatt said in an interview."We hope these trials pave for the way for regulatory body approval of dupilumab for clinical use," she said.
If approved, potential barriers to the use of dupilumab in practice include cost and insurance coverage, education and dissemination of study findings, and limited data on side effects, said Narendra.
COPD - Chronic Obstructive Pulmonary Disease COPD Chronic Obstructive Lung Disease COAD - Chronic Obstructive Airway Disease COAD Lung Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Blood Eosinophils Eosinophil Granulocytes Inhaler Interleukins Biologic Therapy Biologics Asthma Asthmatic Adverse Effects
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Lung Cancer Screening Identifies Pulmonary Comorbidities in High-Risk PopulationA majority of individuals with no reported history of COPD showed evidence of COPD symptoms.
Read more »
Catch-and-Treat Strategy Improves Health in Previously Undiagnosed Asthma and COPDPersons with asthma or COPD found through community outreach had improvements in lung function and quality of life over 1 year in a randomized trial.
Read more »
Central Lateral Thalamotomy Improves Outcomes in Severe Trigeminal NeuralgiaPreliminary findings suggest lateral thalamotomy results in improved outcomes for patients with refractory trigeminal neuralgia.
Read more »
Diversity in surgery teams improves postoperative outcomes in medical care, study findsDoug covers topics from a national angle including politics, consumer issues, stories that cross borders, and news that catches the attention of U.S. lawmakers.
Read more »
Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancerCompared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy -- given before and after surgery -- significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer(NSCLC), according to researchers.
Read more »
Why focusing on broken ATM trades improves your trade outcomesWhat happens next? They highlight the need for precision and timing skills.
Read more »