Duke vs Houston Predictions, Picks, and Odds for March Madness Sweet 16 Matchup

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Duke vs Houston Predictions, Picks, and Odds for March Madness Sweet 16 Matchup
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March Madness picks, odds, and predictions for Duke Blue Devils vs Houston Cougars. March Madness picks, including best bet and SGP.

While the Houston Cougars are the No. 1 seed and a 4-point favorite in this matchup, there are some concerning signs as they gear up for the Sweet 16. We break it all down in our March Madness picks for Duke vs. Houston below.The Duke Blue Devils and Houston Cougars will meet in a thrilling contest to win the right to go to the Elite Eight.. It has faced two non-Power Six opponents but has demolished both.

McCain is the best shooter on this Duke roster, which was on display against James Madison. Against the Dukes, he was simply unconscious. He knocked down eight threes and dropped 30 points. I'm not expecting a repeat of that, but his season-long numbers inspire confidence that he'll cash this bet. Additionally, the one place on paper you can get this Houston defense in the halfcourt is off screens. They rank mostly average defending screens while — as you might imagine — every other area is elite. McCain has thrived off screens this season and has been the most used option on them, too, being the primary option 41% of the time.

If he's not at full strength, he can't exploit Duke's defensive issues in the post. And if the Cougars can't do that, they won't win.Duke vs Houston spread and Over/Under analysis

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