New research links weight loss medications like Ozempic and Wegovy to a greater risk of pancreatitis, gastroparesis, and bowel obstruction. Patients who are losing a more extreme amount of body weight are more at risk for these severe side effects.
Kaitlin Vogel is a health journalist based in New York. Her work has appeared in a variety of publications, including Healthline, Eating Well, Parade, and more.Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years of experience in consumer-facing health and wellness content.New research links weight loss medications like Ozempic and Wegovy to a greater risk of pancreatitis, gastroparesis, and bowel obstruction.
The social conversation surrounding weight loss drugs has continued to increase, but are there gastrointestinal side effects you should be talking about?, many doctors also prescribe them for weight loss. While this is the reason the drugs result in successful weight loss, the function may also contribute to negative side effects.
“These drugs cause gastroparesis, which is advantageous for patients with diabetes to improve the match between glucose and insulin,”The rapid weight loss associated with these medications causes an increased flux of cholesterol through the gallbladder, which can promote the growth ofWhile nausea and vomiting can occur in 10–50% of patients, Messer explained that severe side effects, like pancreatitis and gallstones, are rare. The risk of pancreatitis is approximately 0.
Regarding gastroparesis, patients with long-standing, poorly controlled diabetes are expected to be more at risk for exacerbation of gastroparesis symptoms such as nausea, vomiting, abdominal pain, and bloating, Cash said, because these patients are most at risk for gastroparesis in general. “This is a decision that has to be individualized for each patient in consultation with their healthcare provider and highlights the need for additional research and understanding of how common, or rare, these reported adverse events actually are,” said Cash.“These medications are the only true longevity medications on the market,” Messer stated. “Their impact on physical and emotional health is undeniable.
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