A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).
University of Texas Health Science Center at San AntonioAug 8 2024 A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio .
We knew that the drug has been effective in the treatment of breast cancer, but its usefulness in treatment of resulting brain tumors has been unclear. Our trial, however, revealed that it could achieve concentrations of inhibitors inside the tumors sufficient to benefit patients, and with minimal side effects, which is very promising for new therapy."
Addressing an unmet need Brain tumors originating from breast cancer are frequent, and treatment for these tumors typically involve surgery, radiotherapy and systemic therapies, though these measures often are unsuccessful. Sacituzumab Govitecan is a known antibody-drug conjugate, meaning it's a biopharmaceutical drug designed as a targeted therapy for treating cancer. Unlike chemotherapy, it is intended to target and kill tumor cells while sparing healthy cells. It has been demonstrated to be effective in patients with TROP-2, which is a membrane protein found in many tumors.
"SG could achieve intra-tumoral concentrations of SN-38 sufficient for therapeutic benefit in patients with brain metastases from breast cancer and recurrent glioblastoma," the researchers concluded. "The drug was well-tolerated in this population with promising clinical signals of efficacy."
Breast Cancer Cancer Brain Metastases Chemotherapy Clinical Trial Glioblastoma Glioblastoma Multiforme Neuro-Oncology Oncology Radiotherapy Research Surgery Tumor
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Drug shows promise for treating brain tumors resulting from breast cancer, trial reportsA drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).
Read more »
Blackpool health update shows 'high levels of drug and alcohol abuse'Drug deaths in the Lancashire town are almost four times higher than in the rest of England
Read more »
Mexican drug lord El Chapo's son and his former partner arrested for 'leading drug cartel'Joaquin Guzman Lopez, the son of the notorious drug lord, and Ismael 'El Mayo' Zambada, who co-founded the Sinaloa Cartel with El Chapo, were arrested in Texas, the US Justice Department said.
Read more »
And improved method for anti-cancer drug detection: How tiny tumor models could transform drug testingA team of researchers from Henan University of Science and Technology have introduced a novel method for improving drug testing for esophageal cancer (EC) using advanced three-dimensional (3D) cell culture technology.
Read more »
Diabetes drug reduces drug resistance in lung cancer, improving chemotherapy effectivenessA medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer, according to new findings from the University of Missouri School of Medicine published in Clinical Cancer Research.
Read more »
Increasing clinicians' knowledge about climate change's impact on health and health care sustainabilityAn educational program emphasizing the relationship that climate change has with health and health care environmental sustainability was well-received by physicians, according to a recent survey-based study published in JAMA Network Open and conducted by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General...
Read more »