Drug pipeline 2Q22 — a downturn in approvals - Nature Biotechnology

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Drug pipeline 2Q22 — a downturn in approvals - Nature Biotechnology
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Among the notable approvals in our 2Q22 drug pipeline Data Page are Alnylam's Amvuttra for hATTR amyloidosis, bmsnews's Camzyos, a first-in-class therapy for hypertrophic cardiomyopathy, and LillyPad's Olumiant, the first systemic drug for hair loss

11/30/2022 FDA PDUFA date for this engineered IgG1 anti-PD-1 mAb, which lacks the Fc gamma receptorI-radiolabeled mouse IgG1 mAb targeting B7-H3-expressing immune cells12/28/2022 FDA PDUFA date for this chimeric anti-CD20 IgG1 mAb directed towards the CD20 antigen with the glycosylation profile of LFB-R603 for enhanced ADCC10/01/2022 FDA PDUFA date for this fully human IgG2 against CTLA411/01/2022 FDA PDUFA date for this viral gene therapy consisting of AAV5 vector carrying the human factor IX...

AAV5, adeno-associated virus serotype 5; ADCC, antibody-dependent cell-mediated cytotoxicity; ADC, antibody drug conjugate; B7-H3, B7 homolog 3 protein; CD20, cluster of differentiation 20; CTLA4, cytotoxic T lymphocyte-associated antigen 4; Fc, immunoglobulin crystallizable fragment; IgA, immunoglobulin A; LFB-R603, anti-CD20 mAb; PD-1, programmed cell death protein 1; PDUFA, Prescription Drug User Fee Act.

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