People with diabetes are twice as likely to develop dementia as those without the disease. In a new study, people with newly diagnosed type 2 diabetes who took the diabetes drug pioglitazone were less likely to later develop dementia than those who did not take the drug. The study is published in the February 15, 2023, online issue of Neurology.
"Since dementia develops for years before diagnosis, there may be an opportunity for intervening before it progresses," said study author Eosu Kim, MD, Ph.D., of Yonsei University in Seoul, Republic of Korea."These results may suggest that we could use a personalized approach to preventing dementia in people with diabetes in the case that they have a history of ischemic heart disease or stroke.
For the study, researchers looked at the national Korean health database for people newly diagnosed with type 2 diabetes who did not have dementia. They were followed for an average of 10 years. Of the 91,218 participants, 3,467 received the drug pioglitazone. During the study, 8.3% of the people taking pioglitazone developed dementia, compared to 10.0% of those who were not taking the drug. After researchers accounted for other factors that could affect dementia risk, such as
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