Adding lanreotide to everolimus significantly prolonged progression-free survival compared with everolimus alone in patients with gastroenteropancreatic neuroendocrine tumors, a phase 3 trial found.
Adding the somatostatin analog lanreotide to the mTOR inhibitor everolimus significantly prolonged progression-free survival in patients with unresectable or recurrent gastroenteropancreatic neuroendocrine tumor s compared with everolimus alone.
The standard treatment for grade 1 or 2 nonfunctional, unresectable gastroenteropancreatic neuroendocrine tumors is monotherapy with a targeted therapy, everolimus, or a somatostatin analog.However, the combination of lanreotide and everolimus has not previously been studied, ASCO expert Laura Vater, MD, MPH, with Indiana University Simon Cancer Center, Indianapolis, said in a statement.
Patients were randomly allocated to everolimus monotherapy or to the combination of everolimus and lanreotide . The 1-year survival rate was similar between the two groups — 96.2% in the everolimus plus lanreotide group and 97.0% in the everolimus monotherapy group.A total of 13 events were observed; there were 11 deaths from the primary disease, one death from another disease, and one from an unknown cause, but no treatment-related deaths were reported.Adverse events of grade 3 or higher occurred in 35.6% of patients in the everolimus plus lanreotide group and 14.9% of patients in the everolimus group.
Neuroendocrine Tumour NET Nets Neuroendocrine Tumor (NET) Neuroendocrine Tumors (Nets) Neuroendocrine Tumour (NET) Neuroendocrine Tumours (Nets) Tumor Islet Cell Tumor Gastro-Entero-Pancreatic Neuroendocrine Tumor
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