Cell division is a pivotal moment in the life cycle of a cell: when things go wrong, the cell typically triggers growth arrest or its own self-destruction. Researchers have now discovered a previously unknown process that initiates cancer cell death in two distinct ways.
This newly uncovered mechanism could help fighting blood cancer, as many modern therapies target the last step in cell division in tumor cells.
However, if this process fails, results can be catastrophic. The resulting cells, locked together like Siamese twins, would have twice as many chromosomes and centrosomes, making them unfit and prone to malignancy. Many cancer cells, for example, exhibit abnormal chromosome numbers and extra centrosome. Typically, before such defective cells can survive and grow, they arrest their cell cycle, or trigger their own destruction by an unknown mechanism.
"By analyzing the BID and caspase-2 activity in cancer cells, we could potentially identify patients who are most likely to respond to drugs that interfere with cell division," explains Andreas Villunger, highlighting the potential clinical application of their research."Translating laboratory research into clinical practice is a lengthy and complex process.
Stem Cells Brain Tumor Cancer Lymphoma Leukemia Diseases And Conditions Colon Cancer
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