A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA. Achieving the opposite and stabilizing health-promoting mRNA is still a great challenge.
A commonly used strategy in the development of messenger RNA medicine is based on the destruction of disease-causing mRNA. Achieving the opposite and stabilizing health-promoting mRNA is still a great challenge. A research team has now overcome this challenge: the chemists developed the first active substance that inhibits the deadenylation of mRNA and thus prevents its degradation.
mRNA transports the most valuable cellular information -- the chemical blueprint for the production of proteins -- from the nucleus into the cytoplasm. However, as soon as mRNA has delivered its message to the protein-producing factories in the cytoplasm it is no longer needed and degraded by exonucleases. Depending on how long the mRNA remains in the cytoplasm, more or less of a protein is produced -- be it health-promoting or disease-causing.
Proteins need to interact in a complex manner for a so-called 'messenger RNA' to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines ...
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