Researchers studying the link between the gut microbiome and endometriosis are working on a noninvasive stool test for the condition and may have discovered a promising treatment in the process.
Their approach, which focuses on the link between the gut microbiome and endometriosis, also identified a bacterial metabolite they said might be developed as an oral medication for theIn previous research, Rama Kommagani, PhD, an associate professor in the Department of Pathology & Immunology at Baylor College of Medicine in Houston, worked with a mouse model in which endometrial tissue from donor rodents was injected into the peritoneal space of healthy rodents to induce the disorder.
After identifying hundreds of metabolites in the samples, further analysis revealed a subset of 12 metabolites that consistently differentiated women with and without endometriosis. "In a nutshell, we found a specific set of bacterial metabolites in stool, which could be used towards a noninvasive diagnostic test," Kommagani said."But we also found this distinct, specific metabolite that could be used as a therapeutic molecule.
Bacteria Bacterial Infection Microbiome Microbiota Grant Preventive Screening Screening Surgery Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Children Child Childhood Pediatrics Kids Fatty Acids Immunology Laparoscopy Metabolism Metabolic Minnesota Oregon Pharmacokinetics Tissue Transplantation Transplant Toxicology Toxicity Poisoning Toxins Antibiotics
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