A pilot study shows that individuals conceived via assisted reproduction may have lower cardiorespiratory fitness but similar muscle strength as those conceived spontaneously.
Individuals conceived through assisted reproductive technologies had significantly lower cardiorespiratory fitness than those conceived spontaneously, with no difference in muscle strength, a cohort study showed.
Researchers conducted a single-centre observational cohort study in Germany between 2021 and 2022, including individuals aged 4-26 years without known cardiovascular conditions, who were conceived using ART or spontaneously . They analysed anthropometric measurements, diet quality, levels of physical activity, and sedentary behaviour. The analysis was adjusted for age, birth weight, and Cardiorespiratory fitness was evaluated using the 6-minute walking test and 20-meter shuttle run test . The 6MWT distance, number of 20mSRT laps, estimated maximal oxygen uptake , systolic blood pressure , and pulse rate recovery were analysed.Adherence to the Mediterranean diet, levels of physical activity, and sedentary behaviour were not significantly different between groups."This study indicates a significantly lower CRF in ART participants compared to spontaneously conceived controls. Significant differences in muscle strength were not demonstrated between ART participants and controls," the authors wrote.This non-blinded, multi-investigator study was vulnerable to participation and assessor biases and inter-observer variability. Its wide age range and inclusion of adverse perinatal conditions may have affected the results, and key confounders such as ART modality, parental health, and socioeconomic status were not accounted for. Comorbidities among ART offspring may also have affected the fitness measures.The study was funded by the Deutsche Forschungsgemeinschaft and the Munich Clinician Scientist Program of LMU Munich. One author reported receiving support from various sources. Details are provided in the original article. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see ourUntreated Infertility Linked to Higher Risk for Systemic Autoimmune Rheumatic Disease After Childbirth
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