Experts are still encouraging people to take the drug if prescribed.
NEW YORK -- When Laura Martin tested positive for COVID-19 last month during an extended stay in California, she was prescribed Paxlovid, the highly touted antiviral drug created by Pfizer.
Martin resumed her normal activities, but a week later, she began to feel ill again. When her symptoms worsened, she tested again. In additional analysis of the Paxlovid clinical trial data, the Food and Drug Administration reported that most patients"did not have symptoms at the time of a positive PCR test after testing negative, and, most importantly, there was no increased occurrence of hospitalization or death or development of drug resistance."
Some individuals claimed on Twitter that after their initial symptoms dissipated, leading to a negative test, they are once again testing positive. However, around nine days after his initial positive test, Charness said his patient developed cold symptoms and tested positive again for the virus. "The phenomenon of recrudescence reiterates the importance of following CDC's isolation guidance - anyone who develops symptoms of illness during or after isolation should remain isolated, masked, and seek out testing and clinical care," a representative from the CDC told ABC News in a statement."Anyone who is concerned about having been exposed or who for any other reason wants to determine their infection status should test for COVID-19.
"We've taken a preliminary look at our high-risk data, and so we've seen for example, that we have about an incidence about 2% of that viral load rebound, but we also see the same, or close to the same, percent in the placebo arm. So it's something that's not particularly associated with Paxlovid itself, but may have something to do with the virus itself," Dr.
"We are sufficiently concerned about whether people can transmit, when they're on day 12 and 13 and 15, that we are essentially recommending that when people have a recurrence, a rebound, that they restart their isolation, and isolate until their antigen test is negative," Charness said."We're seeing people whose antigen test stays positive for a week after they rebound, which means that they're well outside the CDC's 10-day guidance.
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