A new meta-analysis found direct oral anticoagulants were less likely than antiplatelet therapy to cause intracranial hemorrhage and reinforced adherence to current guidelines for managing atrial fibrillation.
Direct oral anticoagulant therapy is not associated with a significantly higher risk for intracranial hemorrhage than single-agent antiplatelet therapy. However, DOACs are linked to an increased risk for major hemorrhage.Researchers conducted a systematic review and meta-analysis of nine randomized clinical trials involving 45,494 participants with various cardiovascular conditions.
Trials were selected on the basis of criteria such as a comparison of DOAC therapy with antiplatelet therapy , reporting of bleeding events, enrollment of more than 200 participants, and a minimum follow-up of 30 days.The secondary outcomes included major, fatal, and gastrointestinal hemorrhage; ischemic stroke; and cardiovascular mortality.DOAC therapy was not associated with a significantly increased risk for intracranial hemorrhage compared with antiplatelet therapy .
Among the DOAC agents, rivaroxaban was associated with a significantly increased risk for intracranial hemorrhage and major hemorrhage , whereas dabigatran and apixaban were not linked to a significant increase in risk.
Cerebrovascular Accident CVA - Cerebrovascular Accident Atrial Fibrillation AF Afib A-Fib Afib Afib Atrial Fib Atrial Fibrillation (AF) Atrial Fibrillation (A-Fib) AF - Atrial Fibrillation Intracranial Hemorrhage Intracranial Bleeding Intracranial Haemorrhage Traumatic Brain Injury TBI - Traumatic Brain Injury TBI Hemorrhage Bleeding Gastrointestinal Hemorrhage
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