A series of exploratory studies in human adipocytes indicate that DNA methylation is an important determinant of human obesity and its metabolic complications.
Altered DNA methylation may impact adipocyte cellular functions through genomic and molecular mechanisms.have been hindered by challenges in collecting and isolating cells from human tissue.
Subcutaneous and visceral adipose tissue samples were collected intraoperatively from people with extreme obesity and healthy controls , and adipocyte populations were isolated. The 173 visceral sentinels had a median methylation difference of 7.9% between obese cases and controls, and visceral adipocyte sentinels were also preferentially hypomethylated in obesity.
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