The newly-found communication link between brain cells and immune cells might offer a new way to combat multiple sclerosis.
Multiple sclerosis is a debilitating disease that afflicts nearly 3 million people worldwide. While there is no cure for the disease, researchers at Mount Sinai Hospital and the Mount Sinai School of Medicine believe they have uncovered a new approach for possible treatments in the future., researchers describe how crosstalk between certain brain cells and peripheral immune cells can increase inflammation in the brain and contribute to MS pathology.
When IL-3 and IL-3Ra are deleted, brain inflammation noticeably declines, and the mouse experienced an improvement in its MS symptoms. Using these data, researchers returned to 12 human participants, six without MS and six with MS, and performed single nuclear sequencing of brain cells.
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