Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.
Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.
No longer able to clean the blood of impurities, the Frankensteined kidney becomes a"pathological neuro-immune endocrine organ," as the UVA researchers describe it in a new scientific paper, that can cause serious health problems. But they say their discovery sets the stage for identifying ways to protect the kidney and better treat hypertension.
RAS inhibitors are widely and effectively used for managing high blood pressure. They are quite safe when their use is supervised by a physician, but patients are routinely cautioned to contact their doctors if they notice signs of potential kidney damage such as reduced frequency of urination, swelling in the legs or feet or seizures.
By understanding what is causing the harmful changes in the kidney, scientists are now positioned to find ways to stop it. That could lead to better ways to treat high blood pressure without unwanted side effects, the researchers hope.
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