Researchers have analysed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack. The study, which involved around one million women aged between 50 and 58, is the largest and most comprehensive study of currently prescribed hormonal substances in the world.
The results show that the risks differ depending on the active substance and how the medicine is taken.
Most women go through menopause between the ages of 50 and 60. Levels of the hormone oestrogen fall sharply, increasing the risk of osteoporosis. The low levels can also contribute to health problems such as hot flushes, mood swings and difficulty sleeping. To counteract these health effects, women may be prescribed hormone replacement therapy involving medicines containing hormones or hormone-like substances.
The results show clearly that the risks of hormone replacement therapy vary depending on the type of treatment. "It is important that both doctors and women are aware of the risks of menopausal hormone therapy and, in particular, that the existing drugs carry different risks of blood clots and cardiovascular disease. Tibolone in particular was associated with an increased risk of stroke and heart attack. Tibolone is used in Europe but is not approved in countries such as the United States.
Hormone Disorders Women's Health Heart Disease Gender Difference Behavior Stroke Caregiving
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