Dieting: Cause of the yo-yo effect deciphered

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Dieting: Cause of the yo-yo effect deciphered
Diet And Weight LossEpigeneticsStem Cells
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Researchers have discovered a mechanism behind the yo-yo effect: fat cells have a memory that is based on epigenetics.

Researchers at ETH Zurich have discovered a mechanism behind the yo-yo effect: fat cells have a memory that is based on epigenetics.

Epigenetics is the part of genetics that's based not on the sequence of genetic building blocks but on small yet characteristic chemical markers on these building blocks. The sequence of building blocks has evolved over a long period of time; we all inherit them from our parents. Epigenetic markers, on the other hand, are more dynamic: environmental factors, our eating habits and the condition of our body -- such as obesity -- can change them over the course of the lifetime.

It's not currently possible to change the relevant epigenetic marks in the cell nucleus with drugs and thus erase the epigenetic memory."Maybe that's something we'll be able to do in the future," Hinte says."But for the time being, we have to live with this memory effect." Von Meyenn adds:"It's precisely because of this memory effect that it's so important to avoid being overweight in the first place.

While studying how memories are formed and stored in the brain, a team identified a novel protein folding mechanism that is essential for long term memory storage. The researchers further ...

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