A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer, according to new findings.
A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer , according to new findings from the University of Missouri School of Medicine published inDespite surgical and chemotherapy treatment, more than 50% of non-metastatic, non-small lung cancer patients see recurrences, in large part because of drug-resistant cancer cells. Researchers identified a way to make these cells more susceptible to chemotherapy, said study author Dr.
The study examined 10 non-small cell lung cancer tumors, half of which were identified as drug resistant. The drug-resistant tumors showed overexpression of a certain enzyme, AKR1B10. When treated with the diabetic neuropathy medication, epalrestat, the tumors became less drug resistant, causing their sensitivity to chemotherapy to significantly increase.
"In general, developing new drugs for cancer treatment is an extremely lengthy, expensive and inefficient process," Kaifi said."In contrast, 'repurposing' these drugs to other diseases is much faster and cheaper. In view of overcoming drug resistance, epalrestat can rapidly be advanced to the clinic to improve cure rates in lung cancer patients."
"Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids" was recently published in. In addition to Kaifi, team members from MU included research scientists Kanve Suvilesh, PhD and Yariswamy Manjunath, PhD; PhD students Yulia I.
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