Scientists have developed a molecular clock that records the timing of cellular events at a single-cell resolution.
Cancers are diseases of abnormal cellular growth, and although many are treatable or even curable, their origins are not necessarily clear. Understanding the precise timing of cellular events -- as cells transition from normal to cancerous conditions -- is key to uncovering new treatments or diagnostic opportunities.
Although only a low percentage of precancers progress to cancer, the only current predictor of colorectal cancer progression is the size of polyps -- small clumps of cells that can become cancerous -- in the colon. The researchers developed the precise molecular"clock" to date that records the timing of cellular events at a single-cell resolution.
"Mirazul drove this entire project, from conception through execution," Coffey said."But we couldn't have done this without our collaborators, particularly Mark Magnuson and Qi Liu." Magnuson, Louise B. McGavock Professor and professor of molecular physiology and biophysics, provided expertise in developmental biology. Liu, professor of biostatistics, and her group provided bioinformatics support.
Cancer Lung Cancer Lymphoma Biotechnology And Bioengineering Biology Cell Biology Developmental Biology
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