Antipsychotic polypharmacy has risen globally over 50 years even though the practice is linked to worse outcomes, more side effects, and increased all-cause mortality.
Global antipsychotic polypharmacy use increased significantly from 1970 to 2023, with 25% of antipsychotic users receiving multiple prescriptions, new research shows. Antipsychotic polypharmacy was associated with higher relapse rates, worse functioning, and greater all-cause mortality risk than monotherapy.Researchers analyzed 517 studies published between 1970 and 2023, including 599 individual timepoints.
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Antipsychotics Neuroleptics Neuroleptic Drugs Polypharmacy Patient Safety Adverse Effects Side Effects
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