A monoclonal antibody targeting IFN-beta provided substantial reductions in the skin lesions associated with dermatomyositis in a double-blind, placebo-controlled phase 2 trial. AAD2023 DermTwitter
March 20, 2023
Dermatomyositis, a rare autoimmune inflammatory condition that typically involves both skeletal muscles and skin, is a challenging disease with a diverse set of potential complications.Immunosuppressive and immunomodulatory agents are used with mixed success for myositis, but skin manifestations, which include papular eruptions, heliotrope rash, photoerythema, burning, and pruritus, are often the most troublesome and the most difficult to control.
In this phase 2 trial, patients whose condition was not improved by at least one standard care therapy for skin manifestations of dermatomyositis were eligible if they had moderate to severe disease as measured with the CDASI , according to Mangold. During the study, patients were allowed to remain on a disease modifying antirheumatic drug and/or prednisone if they had been on stable doses and did not change the dose.
For both stages and doses, the response curves of the active treatment groups and the placebo group diverged almost immediately. By 4 weeks, both measures of CDASI reductions on active therapy were significantly improved relative to placebo, and the response curves had a consistent downward slope through the end of the 12-week study, Mangold reported.
A phase 3 study is being planned with the 600 mg dose, according to Mangold, but he acknowledged that regulatory authorities have generally required endpoints for both cutaneous and muscle manifestations in previous trials of therapies for dermatomyositis.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Times Square stakeholders support migrant shelter at Candler BuildingMayor Eric Adams’ announcement last week to use the vacant, landmarked Candler Building at 209-213 W. 42nd St. for migrant housing made us expect that Times Square stakeholders would howl thei…
Read more »
Leading SA: Director of UTSA’s Data Analytics Program talks about cybersecurity threats, TikTokMax Kilger, the director of the Data Analytics Program at UTSA, joined Leading SA to talk all things cyber security, starting with TikTok.
Read more »
Mexican superstar band Mana performs in support of Pajaro Valley flood victimsMexican superstar band Mana performed Saturday at Oakland Arena, one day after SAP Center in San Jose concert. Both shows benefitted Pajaro Valley flood victims.
Read more »
Google Trends Data Reveals Searches for 'Banking Crisis,' 'Bank Runs,' Skyrocket – Bitcoin NewsGoogle Trends shows a sharp increase in queries related to search terms such as 'banking crisis,' 'bank collapse,' and 'bank failure.' BankFailure BankCrisis
Read more »
WHO, advisors urge China to release all COVID-related data after new researchAdvisors to the World Health Organization have urged China to release all information related to the origin of the COVID-19 pandemic after new findings were briefly shared on an international database used to track pathogens.
Read more »
WHO blasts China for withholding info on COVID origin after data pulled offlineThe World Heath Organization is calling for transparency from China after data with clues that could help determine the origin of COVID-19 was suddenly pulled offline.
Read more »