Developing a definition of long-COVID using self-reported symptoms JAMANetwork longcovid PASC definition symptoms covid COVID19 SARSCoV2
By Neha MathurMay 30 2023Reviewed by Lily Ramsey, LLM In a recent article published in JAMA Network, researchers performed a prospective observational cohort study to develop symptom-based criteria to identify post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection cases, otherwise known as long COVID.
Most published PASC studies have fetched inconsistent estimates of PASC prevalence focused on the symptom frequency of an individual due to the lack of a comparison group and their retrospective design. It is equally important to consider that changes in PASC incidence and its manifestations throughout the COVID-19 pandemic varied for several reasons, such as the emergence of new SARS-CoV-2 strains, introduction and subsequent availability of new treatments, and repeat infections.
The team recruited all participants from 85 US sites and asked them to make office visits and complete remote surveys. For this analysis, they considered symptoms with severity threshold frequency ≥2.5%. Finally, they reported symptom frequencies by infection status and used weighted logistic regression to compute adjusted odds ratios .
Symptoms like PEM, fatigue, dizziness, brain fog, and gastrointestinal symptoms showed a>15% absolute difference in frequencies among infected vs. uninfected individuals.
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