Science, Space and Technology News 2024
Metabolism is the “beating heart of the cell”. New research from ELSI retraces the history of metabolism from the primordial Earth to the modern day . The history of compound discovery over time is cyclic, almost resembling an EKG. Credit: NASA’s Goddard Space Flight Center/Francis Reddy/NASA/ESA
The origin of life on Earth has long been a mystery that has eluded scientists. A key question is how much of the history of life on Earth is lost to time. It is quite common for a singleto “phase out” using a biochemical reaction, and if this happens across enough species, such reactions could effectively be “forgotten” by life on Earth.
To construct a model of the evolutionary history of metabolism at the biosphere scale, the research team compiled a database of 12,262 biochemical reactions from the Kyoto Encyclopedia of Genes and Genomes database. Credit: Goldford, J.E., Nat Ecol Evol In order to model the history of biochemistry, ELSI researchers – Specially Appointed Associate Professor Harrison B. Smith, Specially Appointed Associate Professor Liam M.
One way to circumvent this problem is to nudge the stalled chemistry by manually providing modern compounds. The researchers opted for a different approach: They wanted to determine how manywere missing. And their hunt led them back to one of the most important molecules in all of biochemistry: adenosine triphosphate .ATP is the cell’s energy currency because it can be used to drive reactions – like building proteins – that would otherwise not occur in water.
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