Blood cancer specialists face off on the topic of targeted therapies for chronic lymphocytic leukemia.
, two hematologist-oncologists — Inhye Ahn, MD, of Dana-Farber Cancer Institute in Boston, and Kerry A. Rogers, MD, of The Ohio State University in Columbus, Ohio — faced off in a debate. Ahn said the drugs can indeed be discontinued, while Rogers argued against stopping the medications.
In addition, she said, infections can occur, as well as hampered vaccine response, an important risk in the era of the COVID-19 pandemic. The cost of the drugs is high and adds up over time, she said, and continuous use can boost resistance. It's clear that"responses deepen with continued treatment," she said, noting that remission times grow over years of treatment. She highlighted aof patients with CLL who took ibrutinib that found complete remission or complete remission with incomplete hematologic recovery was 7% at 12 months and 34% at 7 years. When patients quit taking the drugs, Rogers said,"you don't get to maximize your patient's response to this treatment.
Chronic Lymphoid Leukemia Cll Chronic Lymphocytic Leukaemia Chronic Lymphoid Leukaemia Biologic Therapy Biologics Leukemia Leukaemia Blood Cancer Tyrosine Kinase Inhibitor Erlotinib Gefitinib Imatinib Su11248 Sunitinib Toxicology Toxicity Poisoning Toxins Targeted Therapy Targeted Cancer Therapy Tyrosine Kinase COVID-19 2019 Novel Coronavirus
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