DASH diet reduces uric acid levels Uricacid DASHDiet hypertension Gout KD Ketogenic diet VLCKD LowCarb Ketogenic diet SciReports
By Pooja Toshniwal PahariaJul 2 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Scientific Reports, researchers performed a meta-analysis to evaluate the effects of the ketogenic diet and dietary approach to stop hypertension diet on serological uric acid levels.
Weight loss measures are considered key contributors to lowering the risk of hyperuricemia, as UA levels often fluctuate according to different dietary habits. In fact, dietary treatments have been shown to alter hyperuricemia and alleviate gout symptoms significantly. Recent research has linked the DASH diet, which includes vegetables, fruits, moderate-protein, and low-fat milk products, to lower UA.
The Cochrane risk of bias tool for RCTs was used to assess bias risks, whereas the Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess evidence quality. Two researchers independently screened the data, with any disagreements resolved by discussion with two other researchers.
DASH diet reduces UA levels, KD is not effective A total of 26,915 records were initially identified. After eliminating irrelevant and duplicate articles, the titles and abstracts of 13,758 studies were screened, following which 257 studies underwent full-text screening. After applying the eligibility criteria, 10 RCTs, including four and six RCTs intervening with the DASH diet and KD, respectively, were considered for the final analysis.
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Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity - BMC BiologyBackground Epigenetic processes are proposed to be a mechanism regulating gene expression during phenotypic plasticity. However, environmentally induced changes in DNA methylation exhibit little-to-no association with differential gene expression in metazoans at a transcriptome-wide level. It remains unexplored whether associations between environmentally induced differential methylation and expression are contingent upon other epigenomic processes such as chromatin accessibility. We quantified methylation and gene expression in larvae of the purple sea urchin Strongylocentrotus purpuratus exposed to different ecologically relevant conditions during gametogenesis (maternal conditioning) and modeled changes in gene expression and splicing resulting from maternal conditioning as functions of differential methylation, incorporating covariates for genomic features and chromatin accessibility. We detected significant interactions between differential methylation, chromatin accessibility, and genic feature type associated with differential expression and splicing. Results Differential gene body methylation had significantly stronger effects on expression among genes with poorly accessible transcriptional start sites while baseline transcript abundance influenced the direction of this effect. Transcriptional responses to maternal conditioning were 4–13 × more likely when accounting for interactions between methylation and chromatin accessibility, demonstrating that the relationship between differential methylation and gene regulation is partially explained by chromatin state. Conclusions DNA methylation likely possesses multiple associations with gene regulation during transgenerational plasticity in S. purpuratus and potentially other metazoans, but its effects are dependent on chromatin accessibility and underlying genic features.
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