Just in time for AACR23 – the final results of the ROAR basket trial led by VivekSubbiah MDAndersonNews show that dabrafenib plus trametinib exhibited tumor-agnostic clinical activity in patients with rare BRAFV800E-mutated cancers.
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Efficacy evaluable population; Primary and expansion cohorts; Investigator assessment Independent radiology assessment.Among 20 responders by investigator assessment, nine patients had disease progression and four died. Seven patients ended their follow-up and were censored. Among 19 responders by independent radiology assessment, 12 patients had disease progression and one died. Six patients ended their follow-up and were censored.
Extended Data Fig. 3 Progression free survival by investigator and independent radiology assessment across tumor cohorts. Efficacy evaluable population: Primary and expansion cohorts in all except low grade glioma and MM which is primary analysis cohort; Investigator assessment Independent radiology assessment. ATC: By investigator assessment in 36 patients, 21 patients had disease progression and six had died without disease progression. Nine patients were censored due to end of follow-up.
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