CREME is a virtual laboratory that allows scientists to simulate specific decreases in gene activity. It offers a powerful new tool for identifying and understanding important parts of the genome. And it could one day give scientists who don't have access to real laboratories the power to make breakthrough discoveries.
CREME is a virtual laboratory that allows scientists to simulate specific decreases in gene activity. It offers a powerful new tool for identifying and understanding important parts of the genome. And it could one day give scientists who don't have access to real laboratories the power to make breakthrough discoveries.
The program is modeled after CRISPR interference , a genetic perturbation technique based on CRISPR. CRISPRi allows biologists to turn down the activity of specific genes in a cell. CREME lets scientists make similar changes in the virtual genome and predicts their effects on gene activity. In other words, it's almost like an AI version of CRISPRi.
"We have these big, powerful models. They're quite compelling at taking DNA sequences and predicting gene expression. But we don't really have any good ways of trying to understand what these models are learning. Presumably, they're making accurate predictions because they've learned a lot of the rules about gene regulation, but we don't actually know what their predictions are based off of.
Genes Human Biology CRISPR Gene Editing Genetics Life Sciences Virtual Reality Computer Modeling Computational Biology
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