KUANTAN: Lynas Rare Earths has announced a planned shutdown of its operations in Malaysia, apart from its mixed rare earth carbonate (MREC) processing, according to its December financial quarter report.
CAR T treatment utilises the body’s own disease-fighting T cells, which are fortified and multiplied in a lab, and then reinjected into the body to fight the cancer. — 123rf.com
Six CAR T therapies have secured US Food and Drug Administration approval to date, and several more are in the pipeline. Now, a University of Pennsylvania research team in the United States, led by School of Engineering and Applied Science associate professor Dr Michael Mitchell, has found a solution that could help CAR T therapies reach their full potential while minimising severe side effects.“Addressing CRS and neurotoxicity without compromising the therapeutic effectiveness of CAR T cells has been a complex challenge,” says Assoc Prof Mitchell.
Study first author and postdoctoral researcher Dr Gong Ningqiang elaborates on the technique: “We attached this sugar molecule to the CAR T cells using metabolic labelling.“When symptoms of CRS begin to manifest, we introduce another molecule – polyethylene glycol – to create the suit of armour, which effectively blocks dangerous interactions between these engineered T-cells, macrophages and the tumour cells themselves.
The team says that their approach offers more than just a safety net for patients, it also opens up a new “therapeutic window” for treatment.
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