CRC in Middle Age Linked to Morning Sickness Pill From '60s, '70s

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CRC in Middle Age Linked to Morning Sickness Pill From '60s, '70s
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Bendectin has been linked to an increased risk of colorectalcancer among middle-aged people who had been exposed to the drug in utero. CRCSM CRC

A common morning sickness pill used in the 1960s and '70s has been linked to an increased risk of colorectal cancer in middle aged people exposed to the drug in utero.

"The goal of our study was to understand why rates of colorectal cancer are increasing in young people," lead researcherMedscape Medical News The investigators crosslinked to the California Cancer Registry to correlate in utero Bendectin exposure to CRC incidence among the women's 18,751 offspring. The researchers then compared CRC rates among the 1014 adults who had been exposed to the drug with those who had not been exposed. Women who had taken Bendectin did so mostly in the first trimester; most patients received one prescription.

Although it's unclear how exposure to the antispasmodic might increase CRC risk decades later, the researchers suspect dicyclomine may be the culprit.

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