Calixcoca, which is in the final stages of study, could be a tool in the addiction treatment package.
The most recent statistics put the number of regular cocaine or crack cocaine users in the world at 20 million. Of these, one in four will become addicted or develop use disorders.
Pre-clinical tests with the new vaccine on animals have already been carried out successfully. At the moment, the research project is trying to get this experimental drug registered with the Brazilian Health Regulatory Agency Anvisa so that clinical trials can begin and is looking for funds to carry them out.
I was already working on the vaccine when scientific research ran into reality: a tragic situation we experienced in Minas Gerais state became another trigger for the vaccine’s development. In 2013, the Public Prosecutor’s Office issued a rule to the Family Courts, obliging doctors to notify cases of births to drug-dependent women, which would take the newborn children into the adoption system.
After discussing the possible immunogenicity - the ability to induce an immune response - of molecular structures called calixarenes, we agreed that he would synthesise a new molecule, called UFMG-V4N2, which is the basis of the Calixcoca vaccine. UFMG-V4N2 is actually a vaccine platform that can virtually be used to produce other vaccines, against methamphetamine, opioid and nicotine addiction, for example, for which we already have molecule designs under study.
The vaccinated rats did not experience the lack of appetite or hyperactivity induced by cocaine, and had 30 per cent more offspring than the unvaccinated rats, which indicates a reduction in miscarriages, placental abruption and other perinatal complications. The antibodies produced were able to block the passage of the drug through the placenta, protecting the mice.
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