COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection Coronavirus Disease COVID mRNA Vaccines TCells NatureComms VHIR_
By Dr. Chinta SidharthanApr 10 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the journal Nature Communications, researchers investigated whether coronavirus disease 2019 messenger ribonucleic acid vaccines induce long-term resident memory T cells in the lungs against severe acute respiratory syndrome coronavirus 2 .
Furthermore, the cellular immunity induced by SARS-CoV-2 infections has been detected in peripheral blood and as resident memory T cells in the lungs, with the number of SARS-CoV-2-specific resident memory T cells correlating to the level of protection. Peptide pools consisting of the SARS-CoV-2 membrane, spike, and nucleotide proteins were used to stimulate the cellular suspensions derived from the lung tissue and the peripheral blood mononuclear cells obtained from the participants to examine the cellular immune responses such as those of interleukins -10, IL-4, and IFNγ. The levels of SARS-CoV-2 spike-protein-specific T cells in lung and peripheral blood samples were also compared.
Results Related StoriesThe results indicated that while the responses of the IFNγ-secreting CD4+ T cells against the SARS-CoV-2 spike protein were similar in the lung samples obtained from convalescing individuals and individuals immunized with the mRNA vaccine, the resident memory T cell phenotype presented less frequently in the lung responses from the vaccinated individuals as compared to those of the convalescing individuals.
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