There has been some concern about the side effects of mRNA COVID-19 vaccines, such as fever and fatigue, which are generally considered normal and transient. However, the relationship between these adverse reactions and antibody production after receiving the vaccine has not been thoroughly studied.
mRNA COVID-19 vaccines are a type of vaccine that uses a small piece of the virus’s genetic material, called messenger RNA , to help the body’s immune system recognize and fight the virus that causes COVID-19. mRNA vaccines have been shown to be effective at preventing COVID-19 infection and have been authorized for use by regulatory agencies around the world.vaccines, such as fever and fatigue, which are generally considered normal and transient.
Immunoglobulin G dynamics in the first week after vaccination by presence or absence of post-vaccination fever. The red and blue lines show the IgG concentration means predicted by the mixed-effects model in the febrile and nonfebrile groups, respectively. The area of each color indicates the 95% confidence interval of the regression curve. Day 0 is a negative value owing to the effect of the modeling prediction.
The subjects were then classified into a “fever” or “non-fever” group based on the survey results. It was found that the fever group was more likely to be younger and had a past history of allergies. Next, antibody levels at different time points in the two groups were analyzed. At 1 week post-vaccination, the fever group had substantially higher antibody counts than the non-fever group.
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