A new SciencePolicyForum presents an analysis of how the push to manufacture COVID19 vaccines is affecting the global supply of key infant and adolescent non-COVID vaccines.
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These input material shortages are due to the rapid scale-up of COVID-19 vaccine manufacturing, exacerbated by distribution challenges. Because suppliers for certain critical components are limited in number and concentrated in a few countries, access was difficult early in the pandemic when goods distribution was greatly constrained. In addition, emergency measures may have contributed to prioritizing the manufacture of COVID-19 vaccines over the manufacture of other products .
Human resources are also limited. Reassignment to COVID-19 vaccine production and testing, facility lockdowns, and absences due to quarantines and illnesses have caused shortages of experienced personnel, including laboratory staff and engineers. These shortages have delayed some manufacture, testing, and release of essential vaccines and continue to constrain capacity.To monitor product quality, some regulators require submission of every vaccine lot for review and release.
In the latter part of 2021, consumables and single-use materials such as bioprocessing bags remain difficult to obtain. If this leads to vaccine shortages, countries may find it more difficult to close immunity gaps, increasing the potential for outbreaks of measles and other vaccine-preventable diseases .Anticipated disruptions reflect expert judgment informed by aggregated data collected from vaccine manufacturers. See supplementary materials for details.
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