Could mutated blood cells hold the key to lower Alzheimer's risk? NatureMedicine StanfordMed alzheimers AD disease bloodcells mutated research
By Neha MathurJun 19 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Medicine, researchers tested whether clonal hematopoiesis of indeterminate potential status was associated with Alzheimer's disease -related pathological changes, e.g., clinical dementia.
The functional alterations in macrophage-like hematopoietic brain cells called microglia are a primary driver of AD risk, as assessed by genome-wide association studies . Also, the team knew the age of all blood donors at the time of the blood draw, their sex, and the apolipoprotein E genotype as covariates for the study model.
Next, the researchers replicated the finding using the AD Sequencing Project data to maximize the power to detect CHIP associations. To this end, they also sequenced 1,776 samples from the DNA derived from the brain. In the former, they found that a higher genetic risk of CHIP was associated with reduced odds of AD and no evidence of a causal effect in this direction in the latter, with respective ORs of 0.90 and 0.97 per 1 log-odds increase in the risk of CHIP, P=3.3 × 10−4, 0.26 using the weighted median estimator.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Benjamin Netanyahu says Intel plans $25bn investment in Israel chip factory\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
Read more »
IndyCar Road America: Palou wins after late-race pass on HertaChip Ganassi Racing\u2019s Alex Palou won the eighth round of the IndyCar Series at Road America, after a perfectly judged late-race pass on early race dominator Colton Herta.
Read more »
IndyCar Road America: Palou wins after late-race pass on HertaChip Ganassi Racing\u2019s Alex Palou won the eighth round of the IndyCar Series at Road America, after a perfectly judged late-race pass on early race dominator Colton Herta.
Read more »
High lipoprotein(a) levels linked to repeated heart disease events in older adultsHigh lipoprotein(a) levels linked to repeated heart disease events in older adults CHDresearch Cardiovascular Health RiskFactors HeartDisease Dubbo Australia CHDPrevention LipidProfile CHD tandfonline
Read more »
Herbal extracts for mental health: Are they safe for pregnant women?Herbal extracts for mental health: Are they safe for pregnant women? MentalHealth Pregnancy Herbal StJohnsWort Valerian Hops Lavender CaliforniaPoppy Hyperforin Hypericin Protopine ValerenicAcid Valtrate Linalool SciReports
Read more »