A new study found that taking aspirin as adjuvant therapy does not improve outcomes for patients with high-risk nonmetastatic breast cancer.
Adjuvant therapy with aspirin offers no protection against recurrence or survival benefit in patients with high-risk nonmetastatic breast cancer , the results of a new phase 3 randomized controlled trial suggest.
"Collectively, evidence from laboratory and epidemiologic studies and randomized trials strongly suggested a role for aspirin to improve breast cancer outcomes, leading to which, to our knowledge, is the first randomized, placebo-controlled trial of aspirin to report results among survivors of breast cancer," Dr Chen and colleagues wrote.
After a median follow-up of almost 3 years, at the first interim analysis, the study was suspended early due to statistical futility. By that timepoint, 253 invasive disease-free survival events occurred in the aspirin group compared with 112 in the placebo group, providing a hazard ratio of 1.27 that was not statistically significant . No statistically significant difference in overall survival was observed . Safety profiles were similar across groups.
Dr Mandelblatt and colleagues went on to explore broader implications beyond breast cancer, including considerations for communication of negative results in other medical specialties, discussions between clinicians and patients regarding aspirin use for non–breast cancer purposes, and questions about the timing of aspirin use and the role of age and biological aging.
Malignant Breast Neoplasm Breast Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Aspirin Acetylsalicylic Acid Breast Mammary Gland Cancer Risk Social Determinants Of Health SDOH Social Determinants Of Health (SDOH) Adjuvant Therapy Health Care Equity
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study: Daily Aspirin May Help Boost the Immune System and Prevent Spread of Colorectal CancerTaking aspirin may help prevent or delay the progression of colorectal cancer, a new study published in the journal 'Cancer' has found. Colorectal cancer rates among people under 50 are going up by 2% each year, and experts don't know why they're rising.
Read more »
Can aspirin help protect against colorectal cancers?A new study details how a daily dose could prevent or delay the progression of the world’s third most common type of cancer.
Read more »
Robotic nerve 'cuffs' could help treat a range of neurological conditionsResearchers have developed tiny, flexible devices that can wrap around individual nerve fibers without damaging them.
Read more »
Cut light pollution and treat glass to help migrating birds, say researchersSpring bird migration has begun. Under cover of darkness, 2.5–3.5 billion birds will fly northward to their breeding grounds in the United States and Canada.
Read more »
No, coughing does not help treat a heart attackOn April 12, 1989, two troopers were killed when a helicopter they were in crashed into the Susquehanna River while searching for a missing person.
Read more »
Stool Transplant Could Help Treat Parkinson's DiseaseThe research team described the results as 'really encouraging.'
Read more »