Key predictors of prediabetes and diabetes after an episode of acute pancreatitis included baseline severity, elevated C-reactive protein and interleukin 6 levels, and subcutaneous fat area.
The development of prediabetes or diabetes after a single episode of acute pancreatitis in youths can be predicted by the baseline severity of pancreatitis, levels of C-reactive protein and interleukin 6 , and subcutaneous fat area.Acute recurrent pancreatitis and chronic pancreatitis are known risk factors for prediabetes or diabetes among youths.
Researchers conducted a prospective cohort study to identify clinical, laboratory, and imaging predictors of prediabetes and diabetes in 187 patients aged 21 years or younger who were enrolled at the Cincinnati Children's Hospital Medical Center, Cincinnati, with a first-time episode of acute pancreatitis.
Blood samples were collected within 48 hours of admission; plasma levels of chemokines and cytokines along with other clinical and laboratory parameters were measured. Overall, 73% and 77% of participants underwent diabetes screening at 3 and 12 months, respectively. Imaging results within 90 days of the initial acute pancreatitis episode also were available and reviewed for 73% of the participants.At 3 months, prediabetes occurred in 15.3% and diabetes occurred in 0.7% of screened patients. At 12 months, prediabetes occurred in 12.5% and diabetes occurred in 3.5% of screened patients.
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Abdominal Infection Acute Pancreatitis Prediabetes Borderline Diabetes Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Chronic Pancreatitis C-Reactive Protein C-Reactive Protein (CRP) Interleukins Preventive Screening Screening Wisconsin Biologic Therapy Biologics Liver Disease Hepatic Impairment Artificial Intelligence Deep Learning
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