Update: Pediatric COVD reference.
Studying MIS-C is challenging, as it is a rare syndrome and patients present at differing times from the time of diagnosis with COVID-19. Outcomes of patients with MIS-C may be difficult to interpret, owing to whether observations were early in the pandemic when little was known regarding treatment, changing therapeutic strategies over time, and geographical differences for available therapies.
An international observational cohort study collected data regarding clinical outcomes. Data regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021 were analyzed, of which 490 cases met the World Health Organization criteria for MIS-C. Among 614 children with suspected MIS-C, 246 received primary treatment with alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone.
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