Controversy Over Whether Breast, Lung, And Prostate Cancer Screening Save Lives

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Controversy Over Whether Breast, Lung, And Prostate Cancer Screening Save Lives
Prostate CancerLung CancerColon Cancer
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Each of these screening tests is designed to find cancers, or precancers, before they become symptomatic, the goal of early detection being to enable clinicians to era...

assistance from Debra Thomas at Manhattan Women's Imaging on E. 37th St. of new cancer cases in the US each year, with lung, colorectal, and breast cancer making up three of the four deadliest such illnesses. Fortunately, we have screening tests for all four of these cancers: mammograms for breast cancer ; the PSA blood test for prostate cancer ; CT scans for lung cancer ; and things like stool blood tests and colonoscopies for colon cancer .

Unfortunately, with one possible exception, experts are not universally convinced that these tests save lives. Here is a picture from aof data from large randomized trials of common cancer screening strategies. According to this analysis, we do not yet know whether mammography, lung imaging, or PSA blood testing saves lives.

Second, prostate cancer typically occurs in older men, many of whom have other serious health problems. Develop an aggressive prostate cancer, and that might simply be “a marker of more generalized biologic fragility.” For example, to confidently determine whether mammography saves lives, Welch and Dey estimate that we would need to enroll almost 2 million patients in a randomized trial; for prostate cancer, that number needs to be closer to 8 million.

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